| Identification | Back Directory | [Name]
VU 0360172 | [CAS]
1309976-62-2 | [Synonyms]
VU 0360172
VU0360172.HCl
VU 0360172 hydrochloride
N-Cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]-3-pyridinecarboxamide hydrochloride
VU0360172 Hydrochloride N-Cyclobutyl-6-[2-(3-fluorophenyl)ethynyl]pyridine-3-carboxamide | [Molecular Formula]
C18H16ClFN2O | [MOL File]
1309976-62-2.mol | [Molecular Weight]
330.79 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
Soluble to 50 mM in DMSO and to 25 mM in ethanol | [form ]
Powder | [color ]
white to beige | [InChI]
1S/C18H15FN2O.ClH/c19-15-4-1-3-13(11-15)7-9-16-10-8-14(12-20-16)18(22)21-17-5-2-6-17;/h1,3-4,8,10-12,17H,2,5-6H2,(H,21,22);1H | [InChIKey]
NBGAPTWZQXSEAA-UHFFFAOYSA-N | [SMILES]
FC1=CC=CC(C#CC2=NC=C(C=C2)C(NC3CCC3)=O)=C1.Cl |
| Hazard Information | Back Directory | [Uses]
VU 0360172 is a an allosteric modulator for mGluR5. Displays efficacy in regulating CNS function in human embryonic kidney cell, rat cortical astrocyte and similar antipsychotic activity in rats. | [Biological Activity]
VU0360172 is a potent (EC50 = 16.6 nM)systemically active positive allosteric modulator (PAM) of the metabotropic glutamate receptor subtype 5 (mGlu5). It is the first orally active mGlu5 PAM to be efficacious in an in vivo preclinical antipsychotic modelproducing a dose-dependent reversal of amphetamine-induced hyperlocomotion. It was also found to reduce absence seizures in WAG/Rij rats and to inhibit pain. | [IC 50]
mGluR5: 16 nM (EC50); mGluR5: 195 nM (Ki) | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|