| Identification | Back Directory | [Name]
13-zido-,,1-rioxa--zatridecanoic acid 9H-luoren--lmethyl ester | [CAS]
1172605-58-1 | [Synonyms]
FmocNH-PEG3-CH2CH2N3
13-zido-,,1-rioxa--zatridecanoic acid 9H-luoren--lmethyl ester
13-Azido-5,8,11-trioxa-2-azatridecanoic acid 9H-fluoro-9-yl methyl ester | [Molecular Formula]
C23H28N4O5 | [MDL Number]
MFCD28964125 | [MOL File]
1172605-58-1.mol | [Molecular Weight]
440.5 |
| Hazard Information | Back Directory | [Biological Activity]
Fmoc-N-amido-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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