ChemicalBook--->CAS DataBase List--->1189561-66-7

1189561-66-7

1189561-66-7 Structure

1189561-66-7 Structure
IdentificationBack Directory
[Name]

(S)-Gossypol (acetic acid)
[CAS]

1189561-66-7
[Synonyms]

(S)-Gossypol (acetic acid)
[Molecular Formula]

C32H34O10
[MOL File]

1189561-66-7.mol
[Molecular Weight]

578.61
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C, protect from light, stored under nitrogen
[solubility ]

DMSO: 50 mg/mL (86.41 mM); Water: < 0.1 mg/mL (insoluble)
[form ]

Solid
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

(S)-Gossypol is the isomer of a natural product Gossypol. (S)-Gossypol binds to the BH3-binding groove of Bcl-xL and Bcl-2 proteins with high affinity.
[IC 50]

Bcl-2; Bcl-xL
[storage]

Store at -20°C, protect from light, stored under nitrogen
[References]

[1] Oliver CL, et al. In vitro effects of the BH3 mimetic, (-)-Gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res. 2004 Nov 15;10(22):7757-63. DOI:10.1158/1078-0432.CCR-04-0551
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