| Identification | Back Directory | [Name]
YSY01A | [CAS]
1194235-46-5 | [Synonyms]
YSY01A
L-Alaninamide, N-(2-pyrazinylcarbonyl)-L-leucyl-N-[(1R)-1-borono-3-methylbutyl]-3-(2-naphthalenyl)- | [Molecular Formula]
C29H38BN5O5 | [MOL File]
1194235-46-5.mol | [Molecular Weight]
547.45 |
| Hazard Information | Back Directory | [Uses]
YSY01A is a proteasome inhibitor that can suppress cancer cell survival by inducing apoptosis (Apoptosis). Its IC50 values are 51.0 nM for HEK293T, 9.2 nM for A549, 5.2 nM for MCF-7, 8.9 nM for MGC-803, and 35.4 nM for PC-3M cells. Additionally, YSY01A eliminates constitutive STAT3 signaling by downregulating gp130 and JAK2 in human A549 lung cancer cells. YSY01A holds promise for research in the field of cancer therapy[1]. | [IC 50]
IL6-beta; JAK2; Stat-3 | [References]
[1] Huang W, et al. Proteasome Inhibitor YSY01A Abrogates Constitutive STAT3 Signaling via Down-regulation of Gp130 and JAK2 in Human A549 Lung Cancer Cells. Front Pharmacol. 2017 Aug 24;8:476. DOI:10.3389/fphar.2017.00476 |
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