| Identification | More | [Name]
2',5'-Dimethoxyacetophenone | [CAS]
1201-38-3 | [Synonyms]
1-(2,5-dimethoxyphenyl)-ethanone
2',5'-DIMETHOXYACETOPHENONE
2,5-DIMETHOXYACETOPHENONE
2-ACETYL-1,4-DIMETHOXYBENZENE
AKOS BBS-00004326
1-(2,5-dimethoxyphenyl)-ethanon
Acetophenone, 2',5'-dimethoxy-
Ethanone,1-(2,5-dimethoxyphenyl)-
2',5'-Dimethoxyacetophenone 1-(2,5-Dimethoxyphenyl)ethan-1-one 2,5-Dimethoxyacetophenone
2'5'-Dimethoxyacetopheone
2,5-DIMETHOXYACETOPHENONEN
2,5 DIMETHOXYACETOPHENONE pure
Methyl 2,5-dimethoxyphenyl ketone
2,5-Dimethoxy acetonphenone | [EINECS(EC#)]
214-858-0 | [Molecular Formula]
C10H12O3 | [MDL Number]
MFCD00008728 | [Molecular Weight]
180.2 | [MOL File]
1201-38-3.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Safety Statements ]
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3 | [Hazard Note ]
Irritant | [TSCA ]
Yes | [HazardClass ]
IRRITANT | [HS Code ]
29145090 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
1-(2,5-DIMETHOXYPHENYL)ETHANOL-->Acetyl chloride-->Acetic anhydride-->Benzene, 2-ethenyl-1,4-diMethoxy--->1,4-Dimethoxybenzene-->Toluene-->Oxygen | [Preparation Products]
(2,5-Dimethoxyphenyl)acetic acid-->2-Propen-1-one, 3-(4-chlorophenyl)-1-(2,5-dimethoxyphenyl)--->1-(2,5-DIMETHOXY-PHENYL)-ETHYLAMINE-->(2E)-3-(3-chlorophenyl)-1-(2,5-dimethoxyphenyl)prop-2-en-1-one-->3-( 2,5-dimethowy-phenyl)-3-oxo-propionic acid ethyl ester-->Benzenemethanamine, 2,5-dimethoxy-α-methyl-, (αS)- |
| Hazard Information | Back Directory | [Chemical Properties]
clear yellow to green-yellow liquid | [Uses]
2'',5''-Dimethoxyacetophenone is a useful building block which has been used in the preparation of pyridine and thieno[2,3-b] pyridine derivatives as anticancer PIM-1 kinase inhibitors, and in the synthesis of anti-cancer and apoptosis-inducing agents. | [Preparation]
Obtained by reaction of dimethyl sulfate with quinacetophenone in the presence of 10% aqueous sodium hydroxide. | [Synthesis]
2',5'-Dimethoxyacetophenone is prepared from Hydroquinone dimethylether and Acetic anhydride with Aluminum chloride catalyst. | [References]
[1] Tetrahedron Letters, 2011, vol. 52, # 38, p. 4954 - 4956
[2] Catalysis Communications, 2012, vol. 20, p. 68 - 70
[3] Tetrahedron Letters, 2013, vol. 54, # 23, p. 2924 - 2928 |
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