| Identification | Back Directory | [Name]
WAY 208466 dihydrochloride | [CAS]
1207064-61-6 | [Synonyms]
WAY-208466 (hydrochloride) | [Molecular Formula]
C17H19ClFN3O2S | [MDL Number]
MFCD20926423 | [MOL File]
1207064-61-6.mol | [Molecular Weight]
383.87 |
| Chemical Properties | Back Directory | [storage temp. ]
Desiccate at -20°C | [solubility ]
Soluble to 80 mM in water and to 80 mM in DMSO | [form ]
Powder | [color ]
Off-white to light yellow | [Water Solubility ]
H2O: 5mg/mL, clear (warmed) | [InChI]
1S/C17H18FN3O2S/c1-20(2)9-10-21-12-16(15-7-4-8-19-17(15)21)24(22,23)14-6-3-5-13(18)11-14/h3-8,11-12H,9-10H2,1-2H3 | [InChIKey]
SFSFIDVAEMDPIP-UHFFFAOYSA-N | [SMILES]
CN(C)CCN1C=C(S(C2=CC=CC(F)=C2)(=O)=O)C3=CC=CN=C31 |
| Safety Data | Back Directory | [WGK Germany ]
WGK 3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Uses]
3-[(3-Fluorophenyl)sulfonyl]-N,N-dimethyl-1H-pyrrolo[2,3-b]pyridine-1-ethanamine Dihydrochloride is the dihydrochloride salt of 3-[(3-Fluorophenyl)sulfonyl]-N,N-dimethyl-1H-pyrrolo[2,3-b]pyridine-1-ethanamine which is a selective 5-HT6 receptor agonist. It has been proven to have antidepressant and anxiolytic effects on rats suggesting its usefulness as a potential antidepressant. | [Biological Activity]
WAY-208466 is a high affinity (Ki = 4.8 nM) 5-HT6 receptor agonist. In HeLa cells expressing cloned human 5-HT6the compound induced cAMP production (EC50 = 7.3 nM; Emax = 100%). WAY-208466 increases cortical GABA levels and exhibits anxiolytic activity in r at studies. | [storage]
Desiccate at RT |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|