| Identification | More | [Name]
Fenazaquin | [CAS]
120928-09-8 | [Synonyms]
FENAZAQUIN
MAGISTER
4-((4-(1,1-dimethylethyl)phenyl)ethoxy)-quinazolin
4-((4-(1,1-dimethylethyl)phenyl)ethoxy)quinazoline
4-(2-(4-(1,1-dimethylethyl)phenyl)ethoxy)quinazoline
4-tert-butylphenethylquinazolin-4-ylether
el436
FENAZAQUIN PESTANAL, 100 MG
FENAZAQUIN ANALYTICAL STANDARD
Quinazoline, 4-2-4-(1,1-dimethylethyl)phenylethoxy-
4-tert-Butyl phenylethyl quinazolin-4-yl ether | [EINECS(EC#)]
410-580-0 | [Molecular Formula]
C20H22N2O | [MDL Number]
MFCD01656049 | [Molecular Weight]
306.4 | [MOL File]
120928-09-8.mol |
| Chemical Properties | Back Directory | [Melting point ]
70-71° (Dreikorn); mp 77.5-80.0° (Gambie) | [Boiling point ]
447.01°C (rough estimate) | [density ]
1.0970 (rough estimate) | [vapor pressure ]
3.4 x l0-6 Pa (25 °C) | [refractive index ]
1.5700 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly) | [form ]
neat | [pka]
2.88±0.30(Predicted) | [Water Solubility ]
0.102 mg l-1 (20 °C, pH 7) | [color ]
White to off-white | [BRN ]
8331263 | [Henry's Law Constant]
2.1×102 mol/(m3Pa) at 25℃, Duchowicz et al. (2020) | [Major Application]
agriculture
environmental | [InChI]
1S/C20H22N2O/c1-20(2,3)16-10-8-15(9-11-16)12-13-23-19-17-6-4-5-7-18(17)21-14-22-19/h4-11,14H,12-13H2,1-3H3 | [InChIKey]
DMYHGDXADUDKCQ-UHFFFAOYSA-N | [SMILES]
CC(C)(C)c1ccc(CCOc2ncnc3ccccc23)cc1 | [LogP]
5.510 | [CAS DataBase Reference]
120928-09-8(CAS DataBase Reference) | [EPA Substance Registry System]
120928-09-8(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
T,N | [Risk Statements ]
R20:Harmful by inhalation.
R25:Toxic if swallowed.
R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment . | [Safety Statements ]
S37:Wear suitable gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S60:This material and/or its container must be disposed of as hazardous waste .
S61:Avoid release to the environment. Refer to special instructions safety data sheet . | [RIDADR ]
UN 2811 6.1/PG 3 | [WGK Germany ]
3 | [RTECS ]
VA1382000 | [REACH Registrations]
Inactive | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral
Acute Tox. 4 Inhalation
Aquatic Acute 1
Aquatic Chronic 1 | [Hazardous Substances Data]
120928-09-8(Hazardous Substances Data) | [Toxicity]
LD50 orally in rats, mice (mg/kg): 134, 1480; dermally in rabbits (mg/kg): >5000; LC50 (96 hr) in bluegill, trout (mg/l): 34.1, 3.8 (Longhurst) |
| Hazard Information | Back Directory | [Description]
Fenazaquin is a quinazoline acaricide. It has a low aqueous solubility but is highly soluble in many organic solvents. It is not volatile and is not expected to leach to groundwater. It may be persistent in soil and water systems depending on local conditions. Its toxicity to terrestrial and aquatic organisms tends to high to moderate. Fenazaquin is moderately toxic to humans via the oral route and, whilst it may be a respiratory tract irritant no chronic effects have been identified. | [Uses]
Acaricide and insecticide. | [Uses]
Fenazaquin is a non-systemic acaricide/insecticide used widely in controlling mites and other related pests in fruits, vegetables and tea. | [Uses]
Fenazaquin is an acaricide mainly used for control of mites
(Eutetranychus, Panonychus and Tetranychus spp.) on pome and citrus
fruits and glasshouse-grown ornamental plants. | [Definition]
ChEBI: Fenazaquin is a member of quinazolines. It has a role as an acaricide and a mitochondrial NADH:ubiquinone reductase inhibitor. | [Mechanism of action]
Mitochondrial complex I electron transport inhibitor | [Synthesis]
A novel method for the preparation of the acaricide fenazaquin:
1) 4-tert-butylphenethyl alcohol (5 g, 28.0 mmol) and THF (200 mL) were added in a 500 ml reactor, and PPh3 (8.80 g, 33.7 mmol) was added in a single addition and N-bro | [Metabolic pathway]
Fenazaquin is a lipophilic compound and hence is immobile in soils and is
not translocated in plants. The main pathways of metabolism involve
cleavage of the bridging group between the quinazoline and phenyl rings,
oxidation of the tert-butyl sustituent and of the heterocyclic portion of the
quinazoline ring and cleavage of that ring. Most of the information is
taken from a pamphlet produced by the manufacturer of the compound in
which full experimental details were not given (DowElanco, 1993). | [Degradation]
Fenazaquin is hydrolysed under acidic conditions but the rate is slow
under neutral and alkaline conditions. Half-lives were 8,442 and 584 days
(22 °C) at pH values of 5, 7 and 9, respectively. Hydrolysis occurs by
cleavage of the ether linkage to form quinazolin-2-ol (2) and an alcohol
(3) as shown in Scheme 1. The major route of degradation in aquatic
environments is by photolysis, the main products (2 and 3) being formed
by cleavage of the ether lmkage and include the alkene (4) (DowElanco,
1993). | [Pesticide Type]
Acaricide; Insecticide |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
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