| Identification | More | [Name]
2-Amino-5-nitrophenol | [CAS]
121-88-0 | [Synonyms]
2-AMINO-5-NITROPENOL
2-AMINO-5-NITROPHENOL
2-HYDROXY-4-NITROANILINE
4-Amino-3-hydroxynitrobenzene
5-NITRO-2-AMINOPHENOL
5-NITRO-O-AMINOPHENOL
CI 76535
2-Amino-5-nirtophenol
2-amino-5-nitro-pheno
3-hydroxy-4-aminonitrobenzene
3-nitro-6-aminophenol
ncic55970
rodolyba
ursolyellowbrowna
2-AMINO-5-NIRTO PHENO
2-Amino-5-nitrophenol
2-Hydroxy-4-nitroaniline
C.I. 76535
C.I. 76535
2-Hydroxy-4-nitroaniline
4-Amino-3-hydroxynitrobenzene
2-AMINO-5-NITROPHENOL, TECH., 90%
2-AMINO-5-NITROPHENOL OEKANAL, 250 MG
2-AMINO-5-NITROPHENOL, 90-95%
2-Amino-5-Nitrophenol95% | [EINECS(EC#)]
204-503-8 | [Molecular Formula]
C6H6N2O3 | [MDL Number]
MFCD00007692 | [Molecular Weight]
154.12 | [MOL File]
121-88-0.mol |
| Chemical Properties | Back Directory | [Appearance]
Brown to rust Crystalline powder | [Melting point ]
198-202 °C (dec.) (lit.) | [Boiling point ]
322.46°C (rough estimate) | [density ]
1.3617 (estimate) | [refractive index ]
1.6890 (rough estimate) | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Crystalline Powder | [pka]
8.08±0.19(Predicted) | [color ]
Rust brown to brown | [Water Solubility ]
insoluble | [Detection Methods]
HPLC | [BRN ]
972974 | [InChI]
InChI=1S/C6H6N2O3/c7-5-2-1-4(8(10)11)3-6(5)9/h1-3,9H,7H2 | [InChIKey]
DOPJTDJKZNWLRB-UHFFFAOYSA-N | [SMILES]
C1(O)=CC([N+]([O-])=O)=CC=C1N | [CAS DataBase Reference]
121-88-0(CAS DataBase Reference) | [IARC]
3 (Vol. 57) 1993 | [EPA Substance Registry System]
121-88-0(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R68:Possible risk of irreversible effects.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S36:Wear suitable protective clothing . | [RIDADR ]
2811 | [WGK Germany ]
2
| [RTECS ]
SJ6302500
| [TSCA ]
Yes | [HS Code ]
29222990 | [Hazardous Substances Data]
121-88-0(Hazardous Substances Data) | [Toxicity]
LD50 oral in rat: > 4gm/kg |
| Hazard Information | Back Directory | [General Description]
Brown amorphous granules or powder. Melting point 198-202°C. | [Reactivity Profile]
2-AMINO-5-NITROPHENOL(121-88-0) is a reducing agent. Incompatible with strong oxidizing agents. Reacts slowly with oxygen in the air at room temperature. Stable at temperatures up to 140°F for two weeks when kept in the dark and under nitrogen. Stable under nitrogen for up to 24 weeks 77°F. Incompatible with strong bases . Incompatible with acid chlorides and acid anhydrides. | [Air & Water Reactions]
Is slowly oxidized by air at room temperature. Insoluble in water. | [Fire Hazard]
Flash point data for this chemical are not available. 2-AMINO-5-NITROPHENOL is probably combustible. | [Chemical Properties]
Brown to rust Crystalline powder | [Uses]
2-Amino-5-nitrophenol has been used as starting material in the synthesis of series of (Z)-2-(substituted aryl)-N-(3-oxo-4-(substituted carbamothioyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl) hydrazine carboxamides, as semi permanent (nonoxidative) hair colorant and as toner in permanent (oxidative) hair dye products, in synthesis of series of 7-benzylamino-2H-1,4-benzoxazin-3(4H)-ones, anticonvulsant agents. Also used as a reactant for, diazotation and coupling reactions, preparation of biologically and pharmacologically active molecules. It is also applied in hair dyes and to make azo dyes. | [Uses]
2-Amino-5-nitrophenol is used in hair dyes and as an intermediate
in preparing azo dyes. | [Uses]
Reactant for:• ;Diazotation and coupling reactions1• ;Preparation of biologically and pharmacologically active molecules2 | [Definition]
ChEBI: 2-Amino-5-nitrophenol is a member of 3-nitrophenols. | [Carcinogenicity]
The potential carcinogenicity of 2-amino-5-nitrophenol
was tested by NTP by oral administration (gavage) in
corn oil to F344/N rats (100 and 200 mg/kg) and B6C3F1
mice (400 and 800 mg/kg) for 2 years. There was some
evidence of carcinogenic activity in low-dose male rats, as
indicated by increased incidence of acinar cell adenomas of
the pancreas. No evidence of carcinogenic activity was found
among female rats and the low-dose groups of male and
female mice. The poor survival rates in the high-dose male
rats and high-dose male and female mice reduced the sensitivity
for detecting potential carcinogenic response. | [Purification Methods]
Crystallise the phenol from water. [Beilstein 13 IV 803.] |
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