| Identification | Back Directory | [Name]
NBI 27914 hydrochloride | [CAS]
1215766-76-9 | [Synonyms]
NBI 27914 hydrochloride,NBI27914 hydrochloride | [Molecular Formula]
C18H20Cl4N4.HCl | [MDL Number]
MFCD03791321 | [MOL File]
1215766-76-9.mol | [Molecular Weight]
470.65 |
| Hazard Information | Back Directory | [Uses]
NBI 27914 Hydrochloride is a selective non-peptide corticotropin-releasing factor 1 (CRF1) antagonist. Shown to block behavioral seizures in vivo. | [in vivo]
NBI 27914 (3~30 mg/kg; i.p.) hydrochloride attenuates the referred abdominal pain at the highest dose tested, it is efficacious both 4 and 24 h post-indomethacin dosing[1].
NBI 27914 (1~10 mg/kg; i.p.) hydrochloride dose dependently attenuates Freund's Complete Adjuvant-induced mechanical hyperalgesia. NBI 27914 (10 mg/kg) hydrochloride reverses the thermal hyperalgesia. NBI 27914 hydrochloride attenuates spinal nerve ligation-induced mechanical hyperalgesia and tactile allodynia with minimal effective doses equal to 5 and 10 mg/kg, respectively[1]. The higher doses of NBI 27914 hydrochloride blocks the behavioral seizures and prevents epileptic discharges in concurrent electroencephalograms recorded from the amygdala[2]. | Animal Model: | Male CD-1 mice (20~25 g)[1] | | Dosage: | 3~30 mg/kg | | Administration: | I.p. | | Result: | Attenuated the referred abdominal pain at the highest dose tested, it was efficacious both 4 and 24 h post-indomethacin dosing.
|
| [IC 50]
CRFR1 | [storage]
Store at RT |
|
|