| Identification | Back Directory | [Name]
SSR-241586 | [CAS]
1239279-30-1 | [Synonyms]
SSR-241586
SSR-241586 HCL
SSR 241586,SSR241586
[1,4'-Bipiperidine]-4'-carboxamide, 1'-[2-[(2R)-4-benzoyl-2-(3,4-dichlorophenyl)-2-morpholinyl]ethyl]-N,N-dimethyl- | [Molecular Formula]
C32H42Cl2N4O3 | [MDL Number]
MFCD30533711 | [MOL File]
1239279-30-1.mol | [Molecular Weight]
601.61 |
| Chemical Properties | Back Directory | [Boiling point ]
719.5±60.0 °C(Predicted) | [density ]
1.233±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
8.32±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
SSR-241586 is an antagonist of neurokinin receptors. SSR-241586 is shown to be active in the treatment of depression, schizophrenia, urinary trouble, emesis, and irritable bowel syndrome (IBS)[1][2]. | [References]
[1] Métro TX, et al. Asymmetric synthesis of an antagonist of neurokinin receptors: SSR 241586. J Org Chem. 2011 Apr 15;76(8):2594-602. DOI:10.1021/jo102471r
[2] Cochi A, et al. Enantioselective synthesis of SSR 241586 by using an organo-catalyzed Henry reaction. Org Lett. 2010 Aug 20;12(16):3693-5. DOI:10.1021/ol101555g |
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