| Identification | Back Directory | [Name]
N-lauroyl-1-deoxysphingosine (M18:1/12:0) | [CAS]
1246298-54-3 | [Synonyms]
N-C12-deoxysphingosine
C12 1-Deoxyceramide (m18:1/12:0)
N-lauroyl-1-deoxysphingosine (M18
N-lauroyl-1-deoxysphingosine (M18:1/12:0)
N-LAUROYL-1-DEOXYSPHINGOSINE (M18:1/12:0);N-C12-DEOXYSPHINGOSINE
Dodecanamide, N-[(1S,2R,3E)-2-hydroxy-1-methyl-3-heptadecen-1-yl]- | [Molecular Formula]
C30H59NO2 | [MDL Number]
MFCD22416687 | [MOL File]
1246298-54-3.mol | [Molecular Weight]
465.8 |
| Chemical Properties | Back Directory | [Boiling point ]
597.1±43.0 °C(Predicted) | [density ]
0.893±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMF: >20 mg/ml; DMSO: >20 mg/ml; Ethanol: >30 mg/ml; Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml; PBS (pH 7.2): <50μg/ml | [form ]
A crystalline solid | [pka]
13.78±0.20(Predicted) |
| Hazard Information | Back Directory | [Description]
C12 1-Deoxyceramide (m18:1/12:0) is a medium-chain atypical ceramide containing a 1-deoxysphingosine (m18:1(4E)) backbone. 1-Deoxysphingolipids are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis. | [References]
[1] REGULA STEINER. Elucidating the chemical structure of native 1-deoxysphingosine.[J]. Journal of Lipid Research, 2016, 57 7: 1194-1203. DOI: 10.1194/jlr.m067033
[2] I. ALECU. Cytotoxic 1-deoxysphingolipids are metabolized by a cytochrome P450-dependent pathway[S][J]. Journal of Lipid Research, 2016, 58 1: 60-71. DOI: 10.1194/jlr.m072421 |
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