| Identification | Back Directory | [Name]
N-palMitoyl-1-deoxysphingosine (M18:1/16:0) | [CAS]
1246298-56-5 | [Synonyms]
N-C16-deoxysphingosine
C16 1-Deoxyceramide (m18:1/16:0)
N-palMitoyl-1-deoxysphingosine (M18
N-palMitoyl-1-deoxysphingosine (M18:1/16:0)
N-PALMITOYL-1-DEOXYSPHINGOSINE (M18:1/16:0);N-C16-DEOXYSPHINGOSINE
Hexadecanamide, N-[(1S,2R,3E)-2-hydroxy-1-methyl-3-heptadecen-1-yl]- | [Molecular Formula]
C34H67NO2 | [MDL Number]
MFCD22416689 | [MOL File]
1246298-56-5.mol | [Molecular Weight]
521.9 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
DMF: >20 mg/ml; DMSO: >20 mg/ml; Ethanol: >30 mg/ml; Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml; PBS (pH 7.2): <50μg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Uses]
C16 1-Deoxyceramide (m18:1/16:0) (C16:0 1-Deoxyceramide) is a lipid molecule, which is composed of a long-chain fatty acid (16:0) and a 1-deoxysphingoid backbone. Deoxyceramide accumulates under the conditions of obesity and type 2 diabetes (T2D). Deoxyceramide is unable to be further metabolized to more complex sphingolipid, and is toxic when accumulates in the body. Deoxyceramide increases in differentiated adipocytes in vitro[1]. | [References]
[1] Hannich JT, et al., Ether lipids, sphingolipids and toxic 1-deoxyceramides as hallmarks for lean and obese type 2 diabetic patients. Acta Physiol (Oxf). 2021 May;232(1):e13610. DOI:10.1111/apha.13610 |
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