| Identification | Back Directory | [Name]
N4-isobutyl-N2-((2-phenylthiazol-4-yl)Methyl)pyriMidine-2,4-diaMine | [CAS]
1262770-73-9 | [Synonyms]
KHS101
KHS101 HCI
KHS101 hcl
KHS-101
(KHS101)
KHS-101;KHS101;KHS 101
N4-isobutyl-N2-((2-phenylthiazol-4-yl)Methyl)pyriMidine-2,4-diaMine
2,4-Pyrimidinediamine, N4-(2-methylpropyl)-N2-[(2-phenyl-4-thiazolyl)methyl]-
N4-(2-Methylpropyl)-N2-[(2-phenyl-1,3-thiazol-4-yl)methyl]pyrimidine-2,4-diamine
4-N-(2-methylpropyl)-2-N-[(2-phenyl-1,3-thiazol-4-yl)methyl]pyrimidine-2,4-diamine | [Molecular Formula]
C18H21N5S | [MDL Number]
MFCD18206916 | [MOL File]
1262770-73-9.mol | [Molecular Weight]
339.46 |
| Chemical Properties | Back Directory | [Boiling point ]
574.8±60.0 °C(Predicted) | [density ]
1.241±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 100mg/mL | [form ]
resin (Sticky) | [pka]
5.76±0.10(Predicted) | [color ]
yellow |
| Hazard Information | Back Directory | [Uses]
KHS101 is a small molecule that accelerates neuronal differentiation. KHS101 can distributes to the brain and resulted in a significant increase in neuronal differentiation[1]. | [in vivo]
KHS101 (6 mg/kg; s.c.; BID for 14 days) distributes to the brain and significantly increases neuronal differentiation in rats in vivo[1]. | Animal Model: | Adult Fisher 344 rats (～10 wk old)[1] | | Dosage: | 6 mg/kg | | Administration: | SC, BID for 14 days | | Result: | Increased neuronal differentiation. Reduced proliferation of NPCs. |
| [References]
[1] Wurdak H, et al. A small molecule accelerates neuronal differentiation in the adult rat. Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16542-7. DOI:10.1073/pnas.1010300107 |
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