| Identification | Back Directory | [Name]
2,5-Cyclohexadiene-1,4-dione, 2,5-dimethyl-, 1-[O-(2-methylbenzoyl)oxime] | [CAS]
321695-37-8 | [Synonyms]
2,5-Cyclohexadiene-1,4-dione, 2,5-dimethyl-, 1-[O-(2-methylbenzoyl)oxime] | [Molecular Formula]
C16H15NO3 | [MOL File]
321695-37-8.mol | [Molecular Weight]
269.3 |
| Hazard Information | Back Directory | [Description]
Poloxin-2 is a potent Plk1 PBD inhibitor. It acts by inducing mitotic arrest and apoptosis in cultured human tumor cells at low micromolar concentrations. | [Uses]
Poloxin-2 is a small molecule Plk1 PBD inhibitor that can effectively induce cell mitotic arrest with an EC50 of approximately 15 μM in HeLa cells. Poloxin-2HT was developed by conjugating a hydrophobic tag (HT) to Poloxin-2, a new application of inhibitors targeting protein-protein interactions. Poloxin-2HT significantly enhanced the effects on cell viability and apoptosis by selectively degrading Plk1 protein, and its effect was stronger than that of untagged Poloxin-2. These data validate hydrophobic tags as a new strategy for targeting and disrupting disease-associated proteins. | [References]
[1] Optimized Plk1 PBD inhibitors based on Poloxin induce mitotic arrest and apoptosis in tumor cells |
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