| Identification | Back Directory | [Name]
m-PEG4-Mal | [CAS]
1263044-81-0 | [Synonyms]
m-PEG4-Mal
m-dPEG4-MAL
m-dPEG??-MAL
1263044-81-0
m-dPEG(R)4-MAL
mPEG4-Maleimide
m-PEG4-amido-Mal
m-PEG4-amino-Mal
Mal-amido-PEG4-Ome
Methyl-PEG4-Maleimide
1H-Pyrrole-1-propanamide, 2,5-dihydro-2,5-dioxo-N-3,6,9,12-tetraoxatridec-1-yl- | [Molecular Formula]
C16H26N2O7 | [MDL Number]
MFCD13185020 | [MOL File]
1263044-81-0.mol | [Molecular Weight]
358.39 |
| Hazard Information | Back Directory | [Description]
m-PEG4-Mal is a PEG linker containing a maleimide group. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The hydrophilic PEG spacer increases solubility in aqueous media. | [Uses]
m-PEG4-amino-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [reaction suitability]
reactivity: thiol reactive
reagent type: chemical modification reagent
reagent type: cross-linking reagent
reactivity: sulfhydryl reactive | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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Sigma-Aldrich
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