| Identification | Back Directory | [Name]
VU 0409106 | [CAS]
1276617-62-9 | [Synonyms]
VU 0409106
3-Fluoro-N-(4-methyl-2-thiazolyl)-5-(5-pyrimidinyloxy)benzamide | [Molecular Formula]
C15H11FN4O2S | [MOL File]
1276617-62-9.mol | [Molecular Weight]
330.34 |
| Chemical Properties | Back Directory | [density ]
1.445±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
6.61±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
VU 0409106 is a novel negative allosteric modulator of metabotropic glutamate receptor subtype 5 (mGlu5). VU0409106 also was effective in a mouse marble burying anxiety behaviour. | [in vivo]
VU0409106 (10 mg/kg; i.p.; once) penetrates the blood-brain barrier (BBB) and demonstrates good brain to plasma ratio that near unity[1]. | Animal Model: | CD-1 mice[1] | | Dosage: | 10 mg/kg (10% Tween 80 formulation) | | Administration: | Intraperitoneal injection. | | Result: | 1.19Pharmacokinetic Parameters of VU0409106 in CD-1 mice[1].
| IP (10 mg/kg) | | Plasma Tmax (h) | 0.25 | | Plasma Cmax (ng/mL) | 1450 | | Brain Tmax (h) | 0.25 | | Brain Cmax (ng/mL) | 1350 | | AUCplasma (ng/mL?h) | 702 | | AUCbrain (ng/mL?h) | 696 | | B/P ratio | 0.99 |
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| [IC 50]
mGlu5: 24 nM (IC50) | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
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| Tel: |
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| Website: |
https://www.bocsci.com |
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