| Identification | Back Directory | [Name]
CU CPT 4a | [CAS]
1279713-77-7 | [Synonyms]
CU CPT 4a
TLR3-IN-1
N-[(3-Chloro-6-fluorobenzo[b]thien-2-yl)carbonyl]-D-phenylalanine
D-Phenylalanine, N-[(3-chloro-6-fluorobenzo[b]thien-2-yl)carbonyl]- | [Molecular Formula]
C18H13ClFNO3S | [MOL File]
1279713-77-7.mol | [Molecular Weight]
377.82 |
| Hazard Information | Back Directory | [Uses]
CU-CPT 4a (TLR3-IN-1) is a potent, highly selective TLR3 signaling inhibitor. CU-CPT 4a represses the expression of downstream signaling pathways mediated by the TLR3/dsRNA complex, including TNF-α and IL-1β[1]. | [Biological Activity]
cu cpt 4a is a selective tlr3 inhibitor with ic50 of 3.44 μm in raw 264.7 cells. it can inhibit tlr3/dsrna complex-mediated downstream signaling pathways and inhibit the production of tnf-α and il-1β in whole cells. it reduces the mortality of crypt cells in mice and reduces gastrointestinal syndrome.[1]. cheng k, wang x, yin h. small-molecule inhibitors of the tlr3/dsrna complex. journal of the american chemical society, 2011, 133(11): 3764-3767.[2]. blockade of tlr3 protects mice from lethal radiation-induced gastrointestinal syndrome. nature communications, 2014, 5. | [IC 50]
TLR3: 3.44 μM (IC50, in RAW 264.7 cells) | [storage]
Store at 4°C | [References]
[1] Yibo Wang, et al. Small-Molecule Modulators of Toll-like Receptors. Acc Chem Res. 2020 May 19;53(5):1046-1055. DOI:10.1021/acs.accounts.9b00631 |
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| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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