| Identification | Back Directory | [Name]
Benzamide, N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-2-fluoro-6-iodo- | [CAS]
2471982-20-2 | [Synonyms]
Benzamide, N-[4-[3,5-bis(trifluoromethyl)phenoxy]phenyl]-2-fluoro-6-iodo- | [Molecular Formula]
C21H11F7INO2 | [MOL File]
2471982-20-2.mol | [Molecular Weight]
569.21 |
| Chemical Properties | Back Directory | [Boiling point ]
427.3±45.0 °C(Predicted) | [density ]
1.713±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 10mg/mL,DMSO: 10mg/mL,DMSO:PBS (pH 7.2) (1:5): 0.15mg/mL,Ethanol: 0.25mg/mL | [form ]
A crystalline solid | [pka]
11.28±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
CU-115 is a potent TLR8 antagonist (IC50=1.04 μM), and shows selective for TLR8 over TLR7 (IC50=>50 μM). CU-115 decreases TNF-α and IL-1β production activated by R-848 in THP-1 cells[1]. | [IC 50]
TLR8: 1.04 μM (IC50); TLR7: 50 μM (IC50) | [References]
[1] Rosaura Padilla-Salinas, et al. Discovery of Novel Small Molecule Dual Inhibitors Targeting Toll-Like Receptors 7 and 8. J Med Chem. 2019 Nov 27;62(22):10221-10244. DOI:10.1021/acs.jmedchem.9b01201 |
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