| Identification | Back Directory | [Name]
N-[4-(3-amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-5-chloro-2-fluorobenzenesulfonamide | [CAS]
1279829-87-6 | [Synonyms]
SGK1IN1,SGK1 IN 1,SGK-1-IN-1
N-[4-(3-amino-2H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-5-chloro-2-fluorobenzenesulfonamide
Benzenesulfonamide, N-[4-(3-amino-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]-5-chloro-2-fluoro- | [Molecular Formula]
C17H12ClFN6O2S | [MOL File]
1279829-87-6.mol | [Molecular Weight]
418.83 |
| Chemical Properties | Back Directory | [Boiling point ]
706.2±70.0 °C(Predicted) | [density ]
1.646±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
5.85±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
SGK1-IN-1 is a highly active and selective inhibitor of SGK-1, with an IC50 of 1 nM. | [IC 50]
SGK1 | [References]
[1] ARYL SULFONOHYDRAZIDES. WO 2013041119 A1.
[2] Halland N, et al. Discovery of N-[4-(1H-Pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-sulfonamides as Highly Active and Selective SGK1 Inhibitors. ACS Med Chem Lett. 2014 Oct 23;6(1):73-8. DOI:10.1021/ml5003376 |
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