| Identification | Back Directory | [Name]
1303512-02-8 | [CAS]
1303512-02-8 | [Synonyms]
Izilendustat
tert-butyl 4-((1-(4-chlorobenzyl)-3-hydroxy-2-oxo-1,2-dihydr
tert-butyl 4-[[1-[(4-chlorophenyl)methyl]-3-hydroxy-2-oxopyridin-4-yl]methyl]piperazine-1-carboxylate
tert-butyl 4-((1-(4-chlorobenzyl)-3-hydroxy-2-oxo-1,2-dihydropyridin-4-yl)methyl)piperazine-1-carboxylate
4-[1-(4-Chloro-benzyl)-3-hydroxy-2-oxo-1,2-dihydro-pyridin-4-ylmethyl]-piperazine-1-carboxylic acid tert-butyl ester
1-Piperazinecarboxylic acid, 4-[[1-[(4-chlorophenyl)methyl]-1,2-dihydro-3-hydroxy-2-oxo-4-pyridinyl]methyl]-, 1,1-dimethylethyl ester
inmmune response,HIF-PH,colitis,prolyl hydroxylase,Inhibitor,HIF-2,HIFs,Hypoxia-inducible factors,inflammatory bowel diseases,HIF/HIF Prolyl-Hydroxylase,Izilendustat,inhibit,HIF- lα | [Molecular Formula]
C22H28ClN3O4 | [MDL Number]
MFCD32876908 | [MOL File]
1303512-02-8.mol | [Molecular Weight]
433.93 |
| Chemical Properties | Back Directory | [Boiling point ]
597.8±50.0 °C(Predicted) | [density ]
1.302±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 25 mg/mL (57.61 mM; ultrasonic and warming and heat to 60°C) | [form ]
Solid | [pka]
8.96±0.53(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Izilendustat is a potent inhibitor of prolyl hydroxylase which can stabilize hypoxia inducible factor- 1 alpha (HIF- lα) and hypoxia inducible factor-2 (HIF-2). Izilendustat has the potential for researching diseases that relate to the body’s inmmune response like colitis and other inflammatory bowel diseases (extracted from patent WO2011057115A1 and WO2011057121A1)[1][1]. | [References]
[1] Joseph H, et al. Prolyl hydroxylase inhibitors. Patent WO2011057115A1.
[2] Joseph H, et al. Compositions and methods for treating colitis. Patent WO2011057121A1. |
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