| Identification | Back Directory | [Name]
CZC-25146 hydrochloride | [CAS]
1330003-04-7 | [Synonyms]
CS-1206
CS-1074
CZC-25146.HCl
CZC-25146 hydrochL
CZC-25146 hydrochloride
CZC-25146 hydrochloride >=98% (HPLC)
CZC-25146; CZC 25146; CZC25146;CZC25146 HYDROCHLORIDE;CZC 25146 HYDROCHLORIDE
N-[2-[[5-Fluoro-2-[[2-Methoxy-4-(4-Morpholinyl)phenyl]aMino]-4-pyriMidinyl]aMino]phenyl]-MethanesulfonaMide hydrochloride
CZC-25146.HCL;N-[2-[[5-FLUORO-2-[[2-METHOXY-4-(4-MORPHOLINYL)PHENYL]AMINO]-4-PYRIMIDINYL]AMINO]PHENYL]-METHANESULFONAMIDE HYDROCHLORIDE | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C22H26ClFN6O4S | [MDL Number]
MFCD22417347 | [MOL File]
1330003-04-7.mol | [Molecular Weight]
524.996 |
| Hazard Information | Back Directory | [Uses]
N-(2-(2-(2-Methoxy-4-morpholinophenylamino)-5-fluoropyrimidin-4-ylamino)phenyl)methanesulfonamide is a compound that acts as an inhibitor of LRRK2, a factor in the expression of Parkinsons’s disease, and is ATP-competitive. | [in vivo]
CZC-25146 (1 mg/kg for i.v.; 5 mg/kg for p.o.; single dosage) exhibits relatively good pharmacokinetic properties and an extensive distribution throughout animal body following intravenous injection into mice[1].
CZC-25146 (250 mg/kg; p.o.; 14 days) reduces the ATZ polymer levels in over expressing human polymeric ATZ mice[3]. | Animal Model: | Male CD-1 mice[1] | | Dosage: | 1 mg/kg for i.v.; 5 mg/kg for p.o. | | Administration: | i.v. and p.o.; single dosage | | Result: | Pharmacokinetic Parameters of CZC-25146 in male CD-1 mice[1].
| i.v. (1 mg/kg) | p.o. (5 mg/kg) | | CL (L/h/kg) | 2.3 | | | Vss (L/kg) | 5.4 | | | t1/2 (h) | 1.6 | 1 | | tmax (h) | 0 | 0.25 | | Cmax (ng/mL) | 154 | 1357 | | AUClast (ng/mL·h) | 419 | 2878 | | AUCinf (ng/mL·h) | 434 | 2894 | | F (%) | | 133 |
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| Animal Model: | Genetically modified male mice (6 weeks; over expressing human polymeric ATZ)[3] | | Dosage: | 250 mg/kg | | Administration: | p.o.; 14 days | | Result: | Dramatically and reproducibly reduced the ATZ polymer levels with an overall reduction from 60% in the control group to 37% |
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| Company Name: |
SPIRO PHARMA
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| Tel: |
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| Website: |
www.spiropharma.com.cn |
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