| Chemical Properties | Back Directory | [Boiling point ]
699.1±55.0 °C(Predicted) | [density ]
1.456±0.06 g/cm3(Predicted) | [solubility ]
DMF: 1 mg/ml | [form ]
A solid | [pka]
10.01±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
(Rac)-Benpyrine, a racemate of Benpyrine, is a potent and orally active TNF-α inhibitor. (Rac)-Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research[1]. | [in vivo]
(Rac)-Benpyrine (Compound 001; 25-50 mg/kg; oral gavage; daily; for 3 weeks; Kunming mice) treatment obviously reduces the inflammatory cytokines IFN-γ, IL-1β and IL-6 in the blood serum, and the anti-inflammatory factor IL-10 is obviously increased, the foot swelling degree of the arthritis part is also obviously slowed down, and the weight index increase caused by the arthritis also has no obvious reduction[1]. | Animal Model: | Kunming mice (7-8 weeks) treated with bovine type II collagen and a CFA complete adjuvant[1] | | Dosage: | 25 mg/kg, 50 mg/kg | | Administration: | Oral gavage; daily; for 3 weeks | | Result: | The inflammatory cytokines IFN-γ, IL-1β and IL-6 in the blood serum were obviously reduced, and the anti-inflammatory factor IL-10 was obviously increased.
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| [References]
[1] Hua Li, et al. Compound with TNF- α inhibitory activity and application. CN111320630A. |
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