| Identification | Back Directory | [Name]
3,5-Pyridinedicarbonitrile, 2-(methyl-2-propyn-1-ylamino)-4-phenyl-6-[[3-[1-(phenylmethyl)-4-piperidinyl]propyl]amino]- | [CAS]
1335032-28-4 | [Synonyms]
3,5-Pyridinedicarbonitrile, 2-(methyl-2-propyn-1-ylamino)-4-phenyl-6-[[3-[1-(phenylmethyl)-4-piperidinyl]propyl]amino]- | [Molecular Formula]
C32H34N6 | [MOL File]
1335032-28-4.mol | [Molecular Weight]
502.65 |
| Hazard Information | Back Directory | [Uses]
Sigma-1 receptor antagonist 6 (Compound 12) is an antagonist of the Sigma-1 receptor (σ1R). Sigma-1 receptor antagonist 6 exerts a robust antiallodynic effect by antagonizing σ1R. Sigma-1 receptor antagonist 6 can be used in neuropathic pain animal models to alleviate mechanical allodynia induced by paclitaxel (HY-B0015)[1]. | [References]
[1] Entrena JM, et al. The proof of concept of 2-{3-[N-(1-benzylpiperidin-4-yl)propyl]amino}-6-[N-methyl-N-(prop-2-yn-1-yl)amino]-4-phenylpyridine-3,5-dicarbonitrile for the therapy of neuropathic pain. Bioorg Chem. 2024 Sep;150:107537. DOI:10.1016/j.bioorg.2024.107537 |
|
|