| Identification | More | [Name]
PIPERAZINE-2-CARBOXYLIC ACID | [CAS]
133525-05-0 | [Synonyms]
2-PIPERAZINECARBOXYLIC ACID
PIPERAZINE-2-CARBOXYLIC ACID
(+/-)-PIPERAZINE-2-CARBOXYLIC ACID HYDROCHLORIDE
R,S-PIPERAZINE-2-CARBOXYLIC ACID
TIMTEC-BB SBB004226
(S)-PIPERAZINE-2-CARBOXYLIC ACID DIHYDROCHLORIDE 98%
Piperazine-2-carboxylicacidHCl | [Molecular Formula]
C5H10N2O2 | [MDL Number]
MFCD00132878 | [Molecular Weight]
130.15 | [MOL File]
133525-05-0.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [Hazard Note ]
Irritant |
| Questions And Answer | Back Directory | [Application]
Piperazine-2-carboxylic acid dihydrochloride can be used as a pharmaceutical synthesis intermediate. The reaction proceeds as follows: Piperazine-2-carboxylic acid dihydrochloride (2 g, 9.8 mmol) and (Boc)₂O (8.6 g, 39.4 mmol) are dissolved in THF (40 mL) and water (40 mL). Sodium bicarbonate (8.31 g, 79.8 mmol) is added. The reaction mixture is magnetically stirred at room temperature for 4 hours, then ethyl acetate is added. The mixture is separated using a separatory funnel. The separated organic phase is washed with saturated brine, dried over anhydrous sodium sulfate, concentrated under reduced pressure, and then separated by silica gel column chromatography. 2.5 g of 1,4-di-tert-butoxycarbonylpiperazine-2-carboxylic acid (13-2) was obtained after purification, with a yield of 78%. LC-MS (ESI): m/z (M+1) 331.2. |
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