| Identification | Back Directory | [Name]
Arylsulfonamide 64B | [CAS]
1342890-83-8 | [Synonyms]
Arylsulfonamide 64B
Benzenesulfonamide, N-cyclobutyl-N-[(2,2-dimethyl-2H-pyrano[3,2-b]pyridin-6-yl)methyl]-3,4-dimethoxy- | [Molecular Formula]
C23H28N2O5S | [MOL File]
1342890-83-8.mol | [Molecular Weight]
444.54 |
| Hazard Information | Back Directory | [Uses]
Arylsulfonamide 64B (HIF inhibitor 64B) is an inhibitor of the hypoxia-induced factor (HIF). Arylsulfonamide 64B inhibits hypoxia/HIF-induced expression of c-Met and CXCR4 and reduces primary tumor growth and metastasis of uveal melanoma mouse model[1]. | [References]
[1] Dong L, Y, et al. Arylsulfonamide 64B Inhibits Hypoxia/HIF-Induced Expression of c-Met and CXCR4 and Reduces Primary Tumor Growth and Metastasis of Uveal Melanoma. Clin Cancer Res. 2019;25(7):2206-2218. DOI:10.1158/1078-0432.CCR-18-1368 |
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