| Identification | Back Directory | [Name]
Dynamin IN-2 | [CAS]
1345853-49-7 | [Synonyms]
Dynamin IN-2
9H-Carbazole-9-ethanol, α-[[[(4-chlorophenyl)methyl]amino]methyl]- | [Molecular Formula]
C22H21ClN2O | [MOL File]
1345853-49-7.mol | [Molecular Weight]
364.87 |
| Hazard Information | Back Directory | [Uses]
Dynamin IN-2 (compound 43), a Wiskostatin.html" class="link-product" target="_blank">Wiskostatin (HY-12534) analogue, is a potent dynamin inhibitor, with an IC50 of 1.0 μM for dynamin I GTPase. Dynamin IN-2 also blocks clathrin mediated endocytosis (CME), with an IC50 of 9.5 μM[1]. | [References]
[1] Cossar PJ, et al. Wiskostatin and other carbazole scaffolds as off target inhibitors of dynamin I GTPase activity and endocytosis. Eur J Med Chem. 2022 Dec 15;247:115001. DOI:10.1016/j.ejmech.2022.115001 |
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