| Identification | Back Directory | [Name]
1-(3,6-dichlorocarbazol-9-yl)-3-[2-(1H-indol-3-yl)ethylamino]propan-2-ol | [CAS]
889797-65-3 | [Synonyms]
DC501
DC 501
DC_501
1-(3,6-dichlorocarbazol-9-yl)-3-[2-(1H-indol-3-yl)ethylamino]propan-2-ol | [Molecular Formula]
C25H23Cl2N3O | [MOL File]
889797-65-3.mol | [Molecular Weight]
452.376 |
| Hazard Information | Back Directory | [Description]
DC_501 is a selective non-nucleoside inhibitor of DNA methyltransferase 1 (DNMT1). | [Uses]
DNMT1-IN-4 is a potent non-nucleoside DNA methyltransferase 1 (DNMT1) inhibitor with an IC50 value of 2.5 μM and selectivity towards other AdoMet-dependent protein methyltransferases. DNMT1-IN-4 significantly inhibits cancer cell proliferation[1]. | [References]
[1] Chen S, ET AL. Identifying novel selective non-nucleoside DNA methyltransferase 1 inhibitors through docking-based virtual screening. J Med Chem. 2014 Nov 13;57(21):9028-41. DOI:10.1021/jm501134e |
|
|