| Identification | More | [Name]
2-METHOXY-5-NITRO-6-PICOLINE | [CAS]
5467-69-6 | [Synonyms]
2-METHOXY-5-NITRO-6-PICOLINE
6-METHOXY-3-NITRO-2-PICOLINE
2-methyl-3-nitro-6-methoxypyridine
6-METHOXY-3-NITRO-2-ICOLINE
6-Methoxy-3-nitro-picoline
6-Methoxy-3-nitro-2-methylpyridine
2-METHOXY-5-NITRO-6-METHYLPYRIDINE
2-METHOXY-5-NITRO-6-PICOLINE (2-METHOXY-6-METHYL-5-NITROPYRIDINE)
6-methoxy-2-methyl-3-nitropyridine
2-Methyl-3-nitro-6-methyoxypyridine | [Molecular Formula]
C7H8N2O3 | [MDL Number]
MFCD03095076 | [Molecular Weight]
168.15 | [MOL File]
5467-69-6.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection . | [HS Code ]
2933399990 |
| Hazard Information | Back Directory | [Synthesis]
2-Methoxy-6-methylpyridine (1.95 g, 15 mmol) was used as starting material and 60% nitric acid (7 mL) was added. The reaction mixture gradually changed to reddish brown color, accompanied by exothermic phenomenon and generation of nitrogen dioxide gas. Subsequently, concentrated sulfuric acid (7 mL) was added slowly. The reaction system was stirred at 80°C overnight. Upon completion of the reaction, the cooled reaction mixture was slowly poured into ice water (70 mL) and neutralized with calcium carbonate. The aqueous phase was extracted with ethyl acetate (3 x 50 mL), the organic phases were combined and dried over anhydrous sodium sulfate. The desiccant was removed by filtration and the organic phase was concentrated to dryness under reduced pressure to give 6-methoxy-2-methyl-3-nitropyridine (2.25 g, 86% yield) as a yellow solid. Nuclear magnetic resonance hydrogen spectroscopy (1H NMR, DMSO-d6) data were as follows: δ 8.3 (d, 1H), 6.8 (d, 1H), 4.0 (s, 3H), 2.7 (s, 3H). | [References]
[1] Patent: WO2004/62665, 2004, A1. Location in patent: Page/Page column 44-45 |
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