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1352221-63-6

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1352221-63-6 Structure

1352221-63-6 Structure
IdentificationBack Directory
[Name]

S-acetyl-PEG6-alcohol
[CAS]

1352221-63-6
[Synonyms]

AcS-PEG6-OH
S-acetyl-PEG6
S-acetyl-PEG6-OH
S-acetyl-PEG6-alcohol
Ethanethioic acid, S-(17-hydroxy-3,6,9,12,15-pentaoxaheptadec-1-yl) ester
[Molecular Formula]

C14H28O7S
[MDL Number]

MFCD22574786
[MOL File]

1352221-63-6.mol
[Molecular Weight]

340.43
Chemical PropertiesBack Directory
[Boiling point ]

441.7±45.0 °C(Predicted)
[density ]

1.134±0.06 g/cm3(Predicted)
[pka]

14.36±0.10(Predicted)
Hazard InformationBack Directory
[Biological Activity]

S-acetyl-PEG6 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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