| Identification | Back Directory | [Name]
Bis-aminooxy-PEG7 | [CAS]
1383980-52-6 | [Synonyms]
Bis-aminooxy-PEG7
Hydroxylamine, O-[23-(aminooxy)-3,6,9,12,15,18,21-heptaoxatricos-1-yl]- | [Molecular Formula]
C16H36N2O9 | [MDL Number]
MFCD30723215 | [MOL File]
1383980-52-6.mol | [Molecular Weight]
400.46 |
| Hazard Information | Back Directory | [Description]
Bis-aminooxy-PEG7 molecule contains two aminooxy groups. The hydrophilic PEG spacer increases solubility in aqueous media. Aminooxy (ONH2) group is reactive with an aldehyde to form an oxime bond or a hydroxylamine linkage under reduction condition Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended. | [Uses]
Bis-aminooxy-PEG7 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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