| Identification | Back Directory | [Name]
PF-4800567 HCl | [CAS]
1391052-28-0 | [Synonyms]
PF-4800567 HCl
PF-4800567 hydrochloride >=98% (HPLC)
3-[(3-chlorophenoxy)methyl]-1-(oxan-4-yl)pyrazolo[3,4-d]pyrimidin-4-amine:hydrochloride | [Molecular Formula]
C17H19Cl2N5O2 | [MDL Number]
MFCD20926348 | [MOL File]
1391052-28-0.mol | [Molecular Weight]
396.27 |
| Hazard Information | Back Directory | [Uses]
PF 4800567 is a selective casein kinase 1ε inhibitor; displays 22-fold greater potency towards CK1ε than CK1δ (IC50 values are 32 and 711 nM for CK1ε and CK1δ respectively). ATP competitive. Displays minimal effect on the circadian clock. | [Biological Activity]
PF-4800567 is a casein kinase 1e (CK1e) selective inhibitor (IC50 = 32 nM) th at is 20 fold selective for the CK1e isoform over CK1d. PF-4800567 blockes CK1e-mediated PER3 nuclear translocationbut does not effect the circadian clock in animal studies.''PF-4800567 is also known as (3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride). It can block the epidermal growth factor receptor (EGFR) at micromolar concentrations. PF-4800567 helps to improve the locomotor stimulant reaction to methamphetamine (MA) and fentanyl. | [storage]
Desiccate at RT |
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| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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