| Identification | Back Directory | [Name]
1-Cyclohexyl-3-(cyclopropylmethyl)-2,3-dihydro-N-[(3-methyl-5-isoxazolyl)methyl]-2-oxo-1H-benzimidazole-5-carboxamide | [CAS]
1394592-04-1 | [Synonyms]
1-Cyclohexyl-3-(cyclopropylmethyl)-2,3-dihydro-N-[(3-methyl-5-isoxazolyl)methyl]-2-oxo-1H-benzimidazole-5-carboxamide
1-cyclohexyl-3-(cyclopropylmethyl)-N-((3-methylisoxazol-5-yl)methyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carboxamide | [Molecular Formula]
C23H28N4O3 | [MOL File]
1394592-04-1.mol | [Molecular Weight]
408.49 |
| Chemical Properties | Back Directory | [Boiling point ]
617.4±55.0 °C(Predicted) | [density ]
1.286±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [form ]
Solid | [pka]
12.95±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
JS11 is an inhibitor for natriuretic polypeptide receptor 1 (Npr1) with an IC50 of 1.9 μM for hNpr1. JS11 ameliorates the pruritus in mouse models[1]. | [References]
[1] Hoon MA, et al., Compositions and methods for the inhibition of pruritus. WO2019090039. |
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| Company Name: |
Bide Pharmatech Ltd.
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| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
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