| Identification | Back Directory | [Name]
NucPE1 | [CAS]
1404091-23-1 | [Synonyms]
NucPE1
NUCPE1?, >98%
Nuclear Peroxy Emerald 1
Nuclear Peroxy Emerald 1, >98% | [Molecular Formula]
C29H30BNO5 | [MDL Number]
MFCD31544335 | [MOL File]
1404091-23-1.mol | [Molecular Weight]
483.36 |
| Chemical Properties | Back Directory | [Boiling point ]
643.5±55.0 °C(Predicted) | [density ]
1.26±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
3.40±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
NucPE1 (Nuclear Peroxy Emerald 1) is a nuclear-localized fluorescent hydrogen peroxide that is specifically localized to cellular nuclei without appended targeting moieties. | [in vivo]
NucPE1 maintains the ability to selectively target nuclei in vivo. NucPE1 imaging reveals a reduction in nuclear H2O2 levels in worms overexpressing sir-2.1 compared to wildtype congeners, supporting a link between this longevity-promoting sirtuin protein and enhanced regulation of nuclear ROS pools[1]. | [References]
[1] Stanicka J, et al. NADPH oxidase-generated hydrogen peroxide induces DNA damage in mutant FLT3-expressing leukemia cells. J Biol Chem. 2015 Apr 10;290(15):9348-61. DOI:10.1074/jbc.M113.510495
[2] Dickinson BC, et al. A nuclear-localized fluorescent hydrogen peroxide probe for monitoring sirtuin-mediated oxidative stress responses in vivo. Chem Biol. 2011 Aug 26;18(8):943-8. DOI:10.1016/j.chembiol.2011.07.005 |
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MedChemExpress
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