| Identification | Back Directory | [Name]
Verosudil | [CAS]
1414854-42-4 | [Synonyms]
Verosudil
Verosudil(AR-12286)
N-(1,2-Dihydro-1-oxo-6-isoquinolinyl)-alpha-(dimethylamino)-3-thiopheneacetamide | [Molecular Formula]
C17H17N3O2S | [MOL File]
1414854-42-4.mol | [Molecular Weight]
327.4 |
| Chemical Properties | Back Directory | [Boiling point ]
625.5±55.0 °C(Predicted) | [density ]
1.328±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:0.0(Max Conc. mg/mL);0.0(Max Conc. mM) | [form ]
Solid | [pka]
13.70±0.20(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
Verosudil (AR-12286) is a potent, selective Rho-kinase (ROCK) inhibitor with Kis of 2 and 2 nM for ROCK1 and ROCK2, respectively. AR-12286 lowers intraocular pressure (IOP) primarily by increasing aqueous humour outflow through the trabecular meshwork[1][2]. | [IC 50]
ROCK1: 2 nM (Ki); ROCK2: 2 nM (Ki); PKA: 69 nM (Ki); MRCKA: 28 nM (Ki); CAM2A: 5855 nM (Ki); PKC theta: 9322 nM (Ki) | [storage]
Store at -20°C | [References]
[1] Lin CW, Sherman B, Moore LA, et al. Discovery and Preclinical Development of Netarsudil, a Novel Ocular Hypotensive Agent for the Treatment of Glaucoma. J Ocul Pharmacol Ther. 2018;34(1-2):40‐51. DOI:10.1089/jop.2017.0023
[2] Kopczynski C, Novack GD, Swearingen D, van Haarlem T. Ocular hypotensive efficacy, safety and systemic absorption of AR-12286 ophthalmic solution in normal volunteers. Br J Ophthalmol. 2013;97(5):567‐572. DOI:10.1136/bjophthalmol-2012-302466 |
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| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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