| Identification | Back Directory | [Name]
Verosudil Hydrochloride | [CAS]
1414854-44-6 | [Synonyms]
AR 12286 hydrochloride
Verosudil Hydrochloride
N-(1,2-Dihydro-1-oxo-6-isoquinolinyl)-alpha-(dimethylamino)-3-thiopheneacetamide hydrochloride | [Molecular Formula]
C17H18ClN3O2S | [MOL File]
1414854-44-6.mol | [Molecular Weight]
363.862 |
| Hazard Information | Back Directory | [Uses]
Verosudil hydrochloride (AR-12286 hydrochloride) is the hydrochloride form of Verosudil (HY-16758). Verosudil hydrochloride is an inhibitor for Rho-kinase (ROCK) with Kis of 2 and 2 nM for ROCK1 and ROCK2, respectively. Verosudil hydrochloride lowers intraocular pressure (IOP) primarily by increasing aqueous humour outflow through the trabecular meshwork[1][2]. | [IC 50]
ROCK1: 2 nM (Ki); ROCK2: 2 nM (Ki) | [References]
[1] Lin CW, Sherman B, Moore LA, et al. Discovery and Preclinical Development of Netarsudil, a Novel Ocular Hypotensive Agent for the Treatment of Glaucoma. J Ocul Pharmacol Ther. 2018;34(1-2):40‐51. DOI:10.1089/jop.2017.0023
[2] Kopczynski C, Novack GD, Swearingen D, van Haarlem T. Ocular hypotensive efficacy, safety and systemic absorption of AR-12286 ophthalmic solution in normal volunteers. Br J Ophthalmol. 2013;97(5):567‐572. DOI:10.1136/bjophthalmol-2012-302466 |
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