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1421676-62-1

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1421676-62-1 Structure

1421676-62-1 Structure
IdentificationBack Directory
[Name]

Propargyl-PEG13-acid
[CAS]

1421676-62-1
[Synonyms]

CAS_1421676-62-1
Propargyl-PEG25-acid
Propargyl-PEG13-acid
[Molecular Formula]

C30H56O15
[MDL Number]

MFCD28385473
[MOL File]

1421676-62-1.mol
Chemical PropertiesBack Directory
[solubility ]

Soluble in Water, DMSO, DCM, DMF
Hazard InformationBack Directory
[Description]

Propargyl-PEG13-acid consists of an alkyne group and a carboxylic acid. The carboxylic acid reacts with amine groups to form amide bonds in the presence of EDC or HATU as an activator. The alkyne group is commonly used in copper catalyzed azide-alkyne Click Chemistry reactions. The hydrophilic PEG units enhance the solubility of the molecule in aqueous media.
[Uses]

Propargyl-PEG-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[IC 50]

PEGs
[References]

[1] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277
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