| Identification | Back Directory | [Name]
Propargyl-PEG10-acid | [CAS]
2055022-18-7 | [Synonyms]
CAS_2055022-18-7
Propargyl-PEG10-acid
Propargyl-PEG9-CH2CH2COOH
4,7,10,13,16,19,22,25,28,31-Decaoxatetratriacont-33-ynoic acid
3-[2-[2-[2-[2-[2-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid | [Molecular Formula]
C24H44O12 | [MDL Number]
MFCD28976690 | [MOL File]
2055022-18-7.mol | [Molecular Weight]
524.6 |
| Chemical Properties | Back Directory | [Boiling point ]
593.9±50.0 °C(Predicted) | [density ]
1.124±0.06 g/cm3(Predicted) | [storage temp. ]
Store at Room Tem. | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [form ]
Liquid
(Density: 1.124±0.06 g/cm3) | [pka]
4.28±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG10-acid is a propargyl PEG linker with a terminal carboxylic acid. The terminal carboxylic acid forms amide bonds with primary amines; activators (EDC or HATU) will be needed. The propargyl group can react with azide-bearing compounds to form stable triazole bonds. | [Uses]
Propargyl-PEG10-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG10-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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