| Identification | Back Directory | [Name]
(2R,3S)-E1R | [CAS]
1424832-60-9 | [Synonyms]
(2R,3S)-E1R
1-Pyrrolidineacetamide, 2-methyl-5-oxo-3-phenyl-, (2R,3S)- | [Molecular Formula]
C13H16N2O2 | [MOL File]
1424832-60-9.mol | [Molecular Weight]
232.28 |
| Chemical Properties | Back Directory | [Boiling point ]
480.0±45.0 °C(Predicted) | [density ]
1.168±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 250 mg/mL (1076.29 mM) | [form ]
Solid | [pka]
15.67±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
(2R,3S)-E1R (Compound 2c) is an enantiomer of E1R. (2R,3S)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders[1]. | [References]
[1] Veinberg G, et al. Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor. Bioorg Med Chem. 2013 May 15;21(10):2764-71. DOI:10.1016/j.bmc.2013.03.016 |
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