| Identification | Back Directory | [Name]
5(S)-HPEPE | [CAS]
143292-98-2 | [Synonyms]
5(S)-HPEPE
5(S)HpEPE,5(S) HpEPE
NKXYOIJDQPQELO-GHWNLOBHSA-N
5S-HYDROPEROXY-6E,8Z,11Z,14Z,17Z-EICOSAPENTAENOIC ACID
6,8,11,14,17-Eicosapentaenoic acid, 5-hydroperoxy-, [S-(E,Z,Z,Z,Z)]- (9CI) | [Molecular Formula]
C20H30O4 | [MDL Number]
MFCD00065834 | [MOL File]
143292-98-2.mol | [Molecular Weight]
334.45 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml |
| Hazard Information | Back Directory | [Description]
5(S)-HpEPE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 5-LO on EPA.1 It is metabolized to LTA5, a key intermediate in the formation of the 5-series leukotrienes. Alternatively, 5(S)-HpEPE is reduced to 5(S)-HEPE by peroxidases. | [Uses]
5(S)-HPEPE is an ester product. | [Definition]
ChEBI: 5S-HpEPE is a HPETE. | [References]
1. Kulkarni, P.S., Kaufman, P.L., and Srinivasan, B.D. Eicosapentaenoic acid metabolism in cynomolgus and rhesus conjunctiva and eyelid J. Ocul. Pharmacol. 3(4),349-356(1987). |
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