| Identification | Back Directory | [Name]
Ethanol, 2-[[3-methoxy-2-propoxy-5-[(2R,5R)-tetrahydro-5-(3,4,5-trimethoxyphenyl)-2-furanyl]phenyl]sulfonyl]-, rel- | [CAS]
143445-03-8 | [Synonyms]
L 668750
Ethanol, 2-[[3-methoxy-2-propoxy-5-[(2R,5R)-tetrahydro-5-(3,4,5-trimethoxyphenyl)-2-furanyl]phenyl]sulfonyl]-, rel- | [Molecular Formula]
C25H34O9S | [MOL File]
143445-03-8.mol | [Molecular Weight]
510.6 |
| Hazard Information | Back Directory | [Uses]
(rel)-MK 287 ((rel)-L-680573) is a relative configuration of MK 287. MK 287, a tetrahydrofuran analog, potently inhibited [3H]C18-PAF binding to human platelet, polymorphonuclear leukocyte (PMN) and lung membranes with Kis of 6.1 nM, 3.2 nM and 5.49 nM, respectively. MK 287 inhibits PAF-induced lethality in mice and PAF-induced bronchoconstriction in guinea pigs[1]. | [References]
[1] S B Hwang, et al. MK 287: a potent, specific, and orally active receptor antagonist of platelet-activating factor. J Lipid Mediat. 1993 Jun;7(2):115-34. PMID:8400114 |
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