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SB 200646 Hydrochloride is a 5-HT2C antagonist. | [in vivo]
SB-200646A (20 mg/kg; intravenous injection; daily; for 21 days; male albino Sprague-Dawley rats) treatment significantly decreases the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons[1].
The i.v. administration of 4-16 mg/kg of SB-200646A significantly increases the firing rate and % events as bursts in spontaneously active VTA dopaminergic neurons and significantly increases the % events as burst in substantia nigra pars compacta (SNC) dopaminergic neurons[1]. | Animal Model: | Male albino Sprague-Dawley rats (200-225 g at the beginning of treatment and 300-350 g at the time of the experiment)[1] | | Dosage: | 20 mg/kg | | Administration: | Intravenous injection; daily; for 21 days | | Result: | Significantly decreased the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons.
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| [IC 50]
5-HT2B Receptor: 7.5 (pKi); 5-HT2C Receptor: 6.9 (pKi); 5-HT2A Receptor: 5.2 (pKi) |
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BOC Sciences
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https://www.bocsci.com |
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