| Identification | Back Directory | [Name]
2-Propen-1-one, 3-(3,4-dihydroxy-2-Methoxyphenyl)-1-[4-hydroxy-3-(3-Methyl-2-butenyl)p henyl]-, (E)- | [CAS]
144506-15-0 | [Synonyms]
(E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]prop-2-en-1-one
2-Propen-1-one, 3-(3,4-dihydroxy-2-Methoxyphenyl)-1-[4-hydroxy-3-(3-Methyl-2-butenyl)p henyl]-, (E)-
2-Propen-1-one, 3-(3,4-dihydroxy-2-methoxyphenyl)-1-[4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-, (2E)- | [Molecular Formula]
C21H22O5 | [MOL File]
144506-15-0.mol | [Molecular Weight]
354.4 |
| Chemical Properties | Back Directory | [Melting point ]
113° | [Boiling point ]
590.0±50.0 °C(Predicted) | [density ]
1.244±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO: 125 mg/mL (352.71 mM) | [form ]
Solid | [pka]
8.38±0.20(Predicted) | [color ]
Light yellow to yellow | [InChI]
InChI=1S/C21H22O5/c1-13(2)4-5-15-12-16(8-10-18(15)23)17(22)9-6-14-7-11-19(24)20(25)21(14)26-3/h4,6-12,23-25H,5H2,1-3H3/b9-6+ | [InChIKey]
RETRVWFVEFCGOK-RMKNXTFCSA-N | [SMILES]
C(C1=CC=C(O)C(C/C=C(/C)\C)=C1)(=O)/C=C/C1=CC=C(O)C(O)=C1OC |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from the rhizome of Glycyrrhiza uralensis Fisch. | [Uses]
Licochalcone D, a flavonoid compound mainly existing in the root of Glycyrrhiza uralensis, is a potent and orally active inhibitor of NF-kappaB (NF-κB) p65. Licochalcone D possesses antioxidant, anti-inflammatory, anti-cancer properties[1][2]. | [in vivo]
Licochalcone D (25 and 50 mg/kg; i.g.; daily for a week) inhibits the tumor growth in a mouse xenograft model of murine melanoma B16F0 cells[2]. | Animal Model: | C57BL/6 mice, B16F0 tumor model[2] | | Dosage: | 25 and 50 mg/kg | | Administration: | Intragastric administration, daily for a week | | Result: | Obviously lowered the tumor growth rates, the tumor growth inhibition rates were calculated to be 32.0 and 54.1% at 25 and 50 mg/kg, respectively. |
| [IC 50]
p65 | [storage]
4°C, protect from light | [References]
[1] Furusawa J, et al. Glycyrrhiza inflata-derived chalcones, Licochalcone A, Licochalcone B and Licochalcone D, inhibit phosphorylation of NF-kappaB p65 in LPS signaling pathway. Int Immunopharmacol. 2009 Apr;9(4):499-507. DOI:10.1016/j.intimp.2009.01.031
[2] Si L, et al. Licochalcone D induces apoptosis and inhibits migration and invasion in human melanoma A375 cells. Oncol Rep. 2018 May;39(5):2160-2170. DOI:10.3892/or.2018.6329 |
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| Company Name: |
cjbscvictory Gold
|
| Telephone: |
13348960310 13348960310 |
| Website: |
www.weikeqi-biotech.com/ |
| Company Name: |
Nanjing LuoDa Chemical Co., Ltd
|
| Telephone: |
025-66016961 13382082786; |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList20138/0_EN.htm |
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