1445846-30-9

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1445846-30-9 Structure

Identification	Back Directory
[Name] GPR84 antagonist 8
[CAS] 1445846-30-9
[Synonyms] GPR84 antagonist 8 GPR84 antagonist 8,GPR-84 antagonist 8 4H-Pyrimido[6,1-a]isoquinolin-4-one, 2-(1,4-dioxan-2-ylmethoxy)-6,7-dihydro-9-(2-pyridinylmethoxy)-
[Molecular Formula] C23H23N3O5
[MDL Number] MFCD31692401
[MOL File] 1445846-30-9.mol
[Molecular Weight] 421.45

Chemical Properties	Back Directory
[Boiling point ] 628.2±65.0 °C(Predicted)
[density ] 1.38±0.1 g/cm3(Predicted)
[storage temp. ] Store at -20°C
[solubility ] DMSO : 5 mg/mL (11.86 mM)
[form ] Solid
[pka] 3.98±0.12(Predicted)
[color ] Off-white to light yellow

Safety Data	Back Directory
[Symbol(GHS) ] GHS07
[Signal word ] Warning
[Hazard statements ] H302-H315-H319-H335
[Precautionary statements ] P261-P305+P351+P338

Hazard Information	Back Directory
[Uses] GPR84 antagonist 8 is a selective GPR84 antagonist.
[References] [1] Recio C, et al. Activation of the Immune-Metabolic Receptor GPR84 Enhances Inflammation and Phagocytosis in Macrophages. Front Immunol. 2018 Jun 20;9:1419. DOI:10.3389/fimmu.2018.01419

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