| Identification | Back Directory | [Name]
Azaphilone-9 | [CAS]
1448460-87-4 | [Synonyms]
Azaphilone-9
6H-2-Benzopyran-6,8(7H)-dione, 7-(acetyloxy)-5-bromo-3-[(1E,3E,5S)-3,5-dimethyl-1,3-heptadien-1-yl]-7-methyl- | [Molecular Formula]
C21H23BrO5 | [MOL File]
1448460-87-4.mol | [Molecular Weight]
435.31 |
| Hazard Information | Back Directory | [Uses]
Azaphilone-9 (AZA-9) is an inhibitor of HuR-ARE RNA interaction (IC50=1.2 μM) by binding RNA-binding protein Hu antigen R (HuR). The HuR-RNA interactions stabilize many oncogenic mRNAs in tumors. Thus Azaphilone-9 potentially inhibit cancer cell growth and progression[1]. | [References]
[1] Kaur K, et al. The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro. PLoS One. 2017 Apr 17;12(4):e0175471. DOI:10.1371/journal.pone.0175471 |
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