| Identification | More | [Name]
Isonicotinamide | [CAS]
1453-82-3 | [Synonyms]
4-PYRIDINE CARBOXAMIDE
4-PYRIDINECARBOXYLIC ACID AMIDE
AURORA KA-3066
ISONICOTINAMIDE
ISONICOTINIC ACID AMIDE
PYRIDINE-4-CARBOXAMIDE
PYRIDINE-4-CARBOXYLIC ACID AMIDE
4-Carbamoylpyridine
gamma-Pyridinecarboxamide
Isonicotinamide99%
pridine-4-Carboxamide | [EINECS(EC#)]
215-926-2 | [Molecular Formula]
C6H6N2O | [MDL Number]
MFCD00006432 | [Molecular Weight]
122.12 | [MOL File]
1453-82-3.mol |
| Chemical Properties | Back Directory | [Appearance]
white crystalline powder | [Melting point ]
155-157 °C(lit.)
| [Boiling point ]
227.52°C (rough estimate) | [density ]
1.2236 (rough estimate) | [refractive index ]
1.5350 (estimate) | [storage temp. ]
Store below +30°C. | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
pK1: 3.61(+1) (20°C) | [color ]
White to Off-White | [Water Solubility ]
191.7 g/L (37 ºC) | [BRN ]
2173 | [Cosmetics Ingredients Functions]
SKIN CONDITIONING | [InChI]
1S/C6H6N2O/c7-6(9)5-1-3-8-4-2-5/h1-4H,(H2,7,9) | [InChIKey]
VFQXVTODMYMSMJ-UHFFFAOYSA-N | [SMILES]
NC(=O)c1ccncc1 | [LogP]
-0.28 | [CAS DataBase Reference]
1453-82-3(CAS DataBase Reference) | [NIST Chemistry Reference]
4-Pyridinecarboxamide(1453-82-3) | [EPA Substance Registry System]
1453-82-3(EPA Substance) |
| Hazard Information | Back Directory | [Chemical Properties]
white crystalline powder | [Application]
Isonicotinamide (pyridine-4-carboxamide) can be used as a heterocyclic building block to synthesize:
4-oxo-1,3-thiazinan-3-yl isonicotinamide derivatives as potential anti-tubercular agents.
Organotin(IV) complexes of isonicotinamide via synthesis of phosphoramidate ligands for various biological activity studies.
Bis-pyridinium isonicotinamide derivatives of 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide as potent reactivators sarin.
Isonicotinamide can also be used as a co-former with active pharmaceutical ingredients (APIs) to prepare co-crystals. | [Uses]
Isonicotinamide is an isomeric analogue of nicotinamide and a metabolite of isonicotinic thioamide. Isonicotinamide strongly inducde apoptosis in human acute myelomonocytic leukemia cells, HL-60. | [Definition]
ChEBI: A pyridinecarboxamide that is the monocarboxylic acid amide derivative of isonicotinic acid. | [Preparation]
synthesis of isonicotinamide: In 6g tert-amyl alcohol, add 100mg ferric oxide, 100mg cobalt tetroxide and 100mg manganese dioxide (mass percentage in the mixture: 4.6%), 60mg 4-cyanopyridine (mass percentage in the mixture: 0.91%), 200uL Water (mass percentage in the mixture: 3.0%), mix well; react at 80°C for 24 hours, the conversion rate of 4-cyanopyridine is 99.0%, and the selectivity of the corresponding Isonicotinamide is 99.0%. | [Purification Methods]
Recrystallise isonicotinamide from hot water or isopropanol (158.5-159o), and dry it in a vacuum at 100o. The picrate crystallises from aqueous EtOH or H2O and has m 217-218o (214-215o). [Beilstein 22 III/IV 527, 22/2 V 195.] |
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Jinan Wald Chemical Co., Ltd. Gold
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0531-88773586 13210588999 |
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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https://www.jkchemical.com |
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Alfa Aesar
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400-6106006 |
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Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
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