| Identification | Back Directory | [Name]
3,6-Diazabicyclo[3.2.2]nonane, 3-[(4-methyl-1H-imidazol-5-yl)methyl]-6-[[5-(1H-pyrazol-3-yl)-2-furanyl]methyl]-, (1R,5S)-rel- | [CAS]
1453028-33-5 | [Synonyms]
DRP1i27
3,6-Diazabicyclo[3.2.2]nonane, 3-[(4-methyl-1H-imidazol-5-yl)methyl]-6-[[5-(1H-pyrazol-3-yl)-2-furanyl]methyl]-, (1R,5S)-rel- | [Molecular Formula]
C20H26N6O | [MOL File]
1453028-33-5.mol | [Molecular Weight]
366.46 |
| Chemical Properties | Back Directory | [Boiling point ]
618.5±50.0 °C(Predicted) | [density ]
1.277±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
13.31±0.10(Predicted) | [color ]
Light yellow to brown |
| Hazard Information | Back Directory | [Uses]
DRP1i27 is a potent inhibitor of human Drp1 (dynamin-related protein 1). DRP1i27 binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury[1]. | [References]
[1] Rosdah AA, et al. A novel small molecule inhibitor of human Drp1. Sci Rep. 2022 Dec 13;12(1):21531. DOI:10.1038/s41598-022-25464-z |
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