| Identification | Back Directory | [Name]
Sch-42495 (racemate) | [CAS]
145841-10-7 | [Synonyms]
Sch-42495 (racemate)
L-Methionine, N-[2-[(acetylthio)methyl]-3-(2-methylphenyl)-1-oxopropyl]-, ethyl ester | [Molecular Formula]
C20H29NO4S2 | [MDL Number]
MFCD00871139 | [MOL File]
145841-10-7.mol | [Molecular Weight]
411.58 |
| Chemical Properties | Back Directory | [Boiling point ]
597.3±50.0 °C(Predicted) | [density ]
1.158±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
13.50±0.46(Predicted) |
| Hazard Information | Back Directory | [Uses]
SCH 42495 racemate is the racemate of SCH 42495. SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester proagent of SCH 42354[1]. | [in vivo]
SCH 42495 (30 mg/kg; oral gavage; twice daily) causes a significant reduction in the pulmonary vascular remodelling and ventricular hypertrophy in hypoxic rats after 10 days[2].
Treatment with SCH 42495 (30 mg/kg; oral gavage; twice daily) leads to a decrease in cardiovascular remodelling secondary to chronic hypoxia in rats[2].
SCH 42495 (oral doses of 1, 3, or 10 mg/kg) produces significant reductions in blood pressure in DOCA-N a hypertensive rats of 22±6, 43±7, and 62±12 mm Hg, respectively[1]. | Animal Model: | Hypoxic rats[2] | | Dosage: | 30 mg/kg | | Administration: | Oral gavage; twice daily for 10 days | | Result: | Caused a significant reduction in the pulmonary vascular remodelling and ventricular hypertrophy.
Led to a decrease in cardiovascular remodelling secondary to chronic hypoxia. |
| [storage]
Store at -20°C | [References]
[1] Watkins RW, et al. Atrial natriuretic factor potentiating and hemodynamic effects of SCH 42495, a new, neutral metalloendopeptidase inhibitor. Am J Hypertens. 1993 May;6(5 Pt 1):357-68. DOI:10.1093/ajh/6.5.357
[2] Thompson JS, et al. Effects of the neutral endopeptidase inhibitor, SCH 42495, on the cardiovascular remodelling secondary to chronic hypoxia in rats. Clin Sci (Lond). 1994 Jul;87(1):109-14. DOI:10.1042/cs0870109 |
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