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1461704-01-7

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1461704-01-7 Structure

1461704-01-7 Structure
IdentificationBack Directory
[Name]

Soravtansine
[CAS]

1461704-01-7
[Synonyms]

Soravtansine
Sulfo-PDBA-DM4
Sulfo-PDBA-DM4, 98%，
Maytansine, N2'-[4-[(3-carboxy-3-sulfopropyl)dithio]-4-methyl-1-oxopentyl]-N2'-deacetyl-
[Molecular Formula]

C42H60ClN3O15S3
[MDL Number]

MFCD32263224
[MOL File]

1461704-01-7.mol
[Molecular Weight]

978.58
Chemical PropertiesBack Directory
[density ]

1.41±0.1 g/cm3(Predicted)
[pka]

0.09±0.50(Predicted)
Hazard InformationBack Directory
[Uses]

Sulfo-PDBA-DM4 is a agent-linker conjugate composed of a potent a tubulin inhibitor DM4 and a linker Sulfo-PDBA to make antibody agent conjugate (ADC). Sulfo-PDBA is a gluthatione cleavable linker.
[IC 50]

Maytansinoids
[References]

[1] Sun X, et al. Effects of Drug-Antibody Ratio on Pharmacokinetics, Biodistribution, Efficacy, and Tolerability of Antibody-Maytansinoid Conjugates. Bioconjug Chem. 2017 May 17;28(5):1371-1381. DOI:10.1021/acs.bioconjchem.7b00062
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