| Identification | More | [Name]
Indole-2-carboxylic acid | [CAS]
1477-50-5 | [Synonyms]
1H-INDOLE-2-CARBOXYLIC ACID
2-CARBOXYINDOLE
2-INDOLECARBOXYLIC ACID
AKOS JY2082713
INDOLE-1H-2-CARBOXYLIC ACID
INDOLE-2-CARBOXYLIC ACID
OTAVA-BB BB7013890553
TIMTEC-BB SBB003953
indole-2-carboxlicacid
Indole-2-carboxylate acid
Indole-3-CarboxylicAcidForBiochemistry
2-IndolecarboxylicAcid:Indole-2-CarboxylicAcid
Indole-2-carboxylic acid, 98+%
2-Indolylformic Acid
NSC 16598
Indole-2-carboxylic
Indole-2-earboxylic acid ethylester | [EINECS(EC#)]
216-030-4 | [Molecular Formula]
C9H7NO2 | [MDL Number]
MFCD00005611 | [Molecular Weight]
161.16 | [MOL File]
1477-50-5.mol |
| Chemical Properties | Back Directory | [Appearance]
Yellow Crystalline Powder | [Melting point ]
202-206 °C(lit.)
| [Boiling point ]
287.44°C (rough estimate) | [density ]
1.2480 (rough estimate) | [refractive index ]
1.5050 (estimate) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
Soluble in clear yellow solution 5% in ethanol, dimethyl sulfoxide and methanol. | [form ]
Crystalline Powder or Crystals | [pka]
4.44±0.30(Predicted) | [color ]
Off-white to yellow to brown | [Detection Methods]
HPLC | [BRN ]
124132 | [InChI]
InChI=1S/C9H7NO2/c11-9(12)8-5-6-3-1-2-4-7(6)10-8/h1-5,10H,(H,11,12) | [InChIKey]
HCUARRIEZVDMPT-UHFFFAOYSA-N | [SMILES]
N1C2=C(C=CC=C2)C=C1C(O)=O | [CAS DataBase Reference]
1477-50-5(CAS DataBase Reference) | [NIST Chemistry Reference]
Indole-2-carboxylic acid(1477-50-5) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS06 | [Signal word ]
Warning | [Hazard statements ]
H301-H311-H315-H319-H335 | [Precautionary statements ]
P261-P280-P301+P310a-P305+P351+P338-P405-P501a | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R21/22:Harmful in contact with skin and if swallowed . | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [RTECS ]
NK7882812 | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29339990 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow Crystalline Powder | [Uses]
• ;Reactant for total synthesis of (±)-dibromophakellin and analogs1• ;Reactant for synthesis of the pyrrolizidine alkaloid (±)-trachelanthamidine2• ;Reactant for stereoselective preparation of renieramycin G analogs3• ;Reactant for preparation of spirooxoindolepyrrolidines via reduction of indole-2-carboxylic acid followed by oxidation, condensation, reduction, amidation and Kharasch radical cyclization4• ;Reactant for Pd-catalyzed cyclization5• ;Reactant for preparation of N,N′-(pentane)diylbis[indolecarboxamide] and N,N′-[phenylenebis( | [Definition]
ChEBI: Indole-2-carboxylic acid is an indolyl carboxylic acid. | [Synthesis Reference(s)]
Tetrahedron Letters, 33, p. 7961, 1992 DOI: 10.1016/S0040-4039(00)74789-7 | [Synthesis]
Indole-2-carboxylic acid is prepared by a two-step condensation–reductive cyclization route: starting from 1-methyl-2-nitrobenzene (1) and diethyl oxalate (2), the intermediate sodium salt of 3-(2-nitrophenyl)-2-oxopropanoic acid (3) is first obtained by condensation, which is then reduced and cyclized to give the target product indole-2-carboxylic acid (4) [1].
 | [IC 50]
NMDA Receptor; Human Endogenous Metabolite | [References]
[1]
Jiang, T., Liu, N., Jiang, Y.-W., Ye, P.-P., Xu, W.-M. (2017). A Practical Synthesis of Indole-2-carboxylic Acid. Organic Preparations and Procedures International, 49(5), 476–478. https://doi.org/10.1080/00304948.2017.1374138 |
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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https://www.jkchemical.com |
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Alfa Aesar
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400-6106006 |
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http://chemicals.thermofisher.cn |
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Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
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Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956 |
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https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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