| Identification | Back Directory | [Name]
(S)-1-((5-chloropyridin-3-yl)methyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one | [CAS]
1523406-39-4 | [Synonyms]
CS-2552
SAR-405
SAR-405;SAR 405
(S)-1-((5-Chloropyridin-3-yl)methyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydr
(S)-1-((5-chloropyridin-3-yl)methyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one
(8S)-9-[(5-Chloro-3-pyridinyl)methyl]-6,7,8,9-tetrahydro-2-[(3R)-3-methyl-4-morpholinyl]-8-(trifluoromethyl)-4H-pyrimido[1,2-a]pyrimidin-4-one
4H-Pyrimido[1,2-a]pyrimidin-4-one, 9-[(5-chloro-3-pyridinyl)methyl]-6,7,8,9-tetrahydro-2-[(3R)-3-methyl-4-morpholinyl]-8-(trifluoromethyl)-, (8S)- | [Molecular Formula]
C19H21ClF3N5O2 | [MDL Number]
MFCD28411361 | [MOL File]
1523406-39-4.mol | [Molecular Weight]
443.85 |
| Chemical Properties | Back Directory | [Boiling point ]
526.5±60.0 °C(Predicted) | [density ]
1.51±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
≥22.19 mg/mL in DMSO; insoluble in H2O; ≥32.25 mg/mL in EtOH with ultrasonic | [form ]
Powder | [pka]
3.29±0.20(Predicted) | [color ]
Off-white to light yellow | [InChI]
1S/C19H21ClF3N5O2/c1-12-11-30-5-4-26(12)16-7-17(29)27-3-2-15(19(21,22)23)28(18(27)25-16)10-13-6-14(20)9-24-8-13/h6-9,12,15H,2-5,10-11H2,1H3/t12-,15+/m1/s1 | [InChIKey]
SPDQRCUBFSRAFI-DOMZBBRYSA-N | [SMILES]
FC(F)(F)[C@H]1N(c3[n]([c](cc(n3)N4[C@@H](COCC4)C)=O)CC1)Cc2cncc(c2)Cl |
| Hazard Information | Back Directory | [Uses]
SAR 405 is an anticancer agent and a phosphoinositide 3-kinase (PI3K) inhibitor. | [Biological Activity]
Cell permeable: yes''Primary Target
VPS34 | [IC 50]
Vps34: 1.2 nM (IC50); Vps34: 1.5 nM (Kd); Autophagy |
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